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Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
Petrigliano, Frank A; Liu, Nancy Q; Lee, Siyoung; Tassey, Jade; Sarkar, Arijita; Lin, Yucheng; Li, Liangliang; Yu, Yifan; Geng, Dawei; Zhang, Jiankang; Shkhyan, Ruzanna; Bogdanov, Jacob; Van Handel, Ben; Ferguson, Gabriel B; Lee, Youngjoo; Hinderer, Svenja; Tseng, Kuo-Chang; Kavanaugh, Aaron; Crump, J Gage; Pyle, April D; Schenke-Layland, Katja; Billi, Fabrizio; Wang, Liming; Lieberman, Jay; Hurtig, Mark; Evseenko, Denis.
Affiliation
  • Petrigliano FA; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Liu NQ; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Lee S; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Tassey J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Sarkar A; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Lin Y; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Li L; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
  • Yu Y; Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
  • Geng D; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Zhang J; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
  • Shkhyan R; Department of Orthopaedics, Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, 211100, China.
  • Bogdanov J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Van Handel B; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
  • Ferguson GB; Department of Orthopaedic Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
  • Lee Y; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Hinderer S; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
  • Tseng KC; Department of Orthopaedic Surgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
  • Kavanaugh A; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Crump JG; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Pyle AD; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Schenke-Layland K; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Billi F; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Wang L; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Lieberman J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
  • Hurtig M; The Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany.
  • Evseenko D; Department of Stem Cell Research and Regenerative Medicine, USC, Los Angeles, CA, 90033, USA.
NPJ Regen Med ; 6(1): 77, 2021 Nov 23.
Article in En | MEDLINE | ID: mdl-34815400
ABSTRACT
Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Regen Med Year: 2021 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Regen Med Year: 2021 Type: Article Affiliation country: United States