Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology.

Feng, Shuang; Manley, James L

Feng, Shuang; Manley, James L.

Affiliation

Feng S; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Manley JL; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Genes Dev ; 35(23-24): 1579-1594, 2021 12 01.

Article in En | MEDLINE | ID: mdl-34819354

Subject(s)

R-Loop Structures; Replication Protein A; Cell Nucleolus/metabolism; DNA Helicases/genetics; DNA Helicases/metabolism; DNA, Ribosomal/genetics; DNA, Ribosomal/metabolism; Humans; Multifunctional Enzymes; RNA Helicases/metabolism; RNA, Ribosomal/genetics; RNA, Ribosomal/metabolism; Replication Protein A/genetics; Replication Protein A/metabolism; Transcription, Genetic

Key words

R loop; RNA polymerase I (RNAP I); RNaseH1; replication protein A (RPA); senataxin (SETX)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Replication Protein A / R-Loop Structures Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United States

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