Mechanism for the activation of the anaplastic lymphoma kinase receptor.

Reshetnyak, Andrey V; Rossi, Paolo; Myasnikov, Alexander G; Sowaileh, Munia; Mohanty, Jyotidarsini; Nourse, Amanda; Miller, Darcie J; Lax, Irit; Schlessinger, Joseph; Kalodimos, Charalampos G

Reshetnyak, Andrey V; Rossi, Paolo; Myasnikov, Alexander G; Sowaileh, Munia; Mohanty, Jyotidarsini; Nourse, Amanda; Miller, Darcie J; Lax, Irit; Schlessinger, Joseph; Kalodimos, Charalampos G.

Affiliation

Reshetnyak AV; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rossi P; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Myasnikov AG; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sowaileh M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mohanty J; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.
Nourse A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lax I; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.
Schlessinger J; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. joseph.schlessinger@yale.edu.
Kalodimos CG; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. babis.kalodimos@stjude.org.

Nature ; 600(7887): 153-157, 2021 12.

Article in En | MEDLINE | ID: mdl-34819673

Subject(s)

Anaplastic Lymphoma Kinase/chemistry; Anaplastic Lymphoma Kinase/metabolism; Anaplastic Lymphoma Kinase/ultrastructure; Binding Sites; Cell Membrane/chemistry; Cell Membrane/metabolism; Cryoelectron Microscopy; Crystallography, X-Ray; Cytokines/chemistry; Cytokines/metabolism; Cytokines/ultrastructure; Enzyme Activation; Humans; Ligands; Models, Molecular; Multiprotein Complexes/chemistry; Multiprotein Complexes/metabolism; Multiprotein Complexes/ultrastructure; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Domains; Protein Multimerization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anaplastic Lymphoma Kinase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2021 Type: Article Affiliation country: United States

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