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Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity.
Chan, Pei-Chi; Hung, Li-Man; Huang, Jiung-Pang; Day, Yuan-Ji; Yu, Chao-Lan; Kuo, Feng-Chih; Lu, Chieh-Hua; Tian, Yu-Feng; Hsieh, Po-Shiuan.
Affiliation
  • Chan PC; Department of Physiology and Biophysics, National Defense Medical Center (NDMC), Taipei, Taiwan.
  • Hung LM; Department and Graduate Institute of Biomedical Sciences and Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Huang JP; Department and Graduate Institute of Biomedical Sciences and Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Day YJ; Department of Anesthesiology, Tung's Taichung Metro Harber Hospital, Taichung, Taiwan.
  • Yu CL; Department and Graduate Institute of Biomedical Sciences and Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Kuo FC; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, NDMC, Taipei, Taiwan.
  • Lu CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, NDMC, Taipei, Taiwan.
  • Tian YF; Division of General Surgery, Department of Surgery, Yung Kung Campus, Chi-Mei Medical Center, Tainan, Taiwan; Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
  • Hsieh PS; Department of Physiology and Biophysics, National Defense Medical Center (NDMC), Taipei, Taiwan.
Clin Sci (Lond) ; 136(1): 121-137, 2022 01 14.
Article in En | MEDLINE | ID: mdl-34821367
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipose Tissue, Brown / Insulin Resistance / Chemokine CCL5 / Receptors, CCR5 / Obesity Limits: Animals Language: En Journal: Clin Sci (Lond) Year: 2022 Type: Article Affiliation country: Taiwan
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipose Tissue, Brown / Insulin Resistance / Chemokine CCL5 / Receptors, CCR5 / Obesity Limits: Animals Language: En Journal: Clin Sci (Lond) Year: 2022 Type: Article Affiliation country: Taiwan