Peptide-Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity.

Voss, Saan; Rademann, Jörg; Nitsche, Christoph

Voss, Saan; Rademann, Jörg; Nitsche, Christoph.

Affiliation

Voss S; Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Rademann J; Department of Biology, Chemistry and Pharmacy, Institute of Pharmacy, Medicinal Chemistry, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
Nitsche C; Department of Biology, Chemistry and Pharmacy, Institute of Pharmacy, Medicinal Chemistry, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.

Angew Chem Int Ed Engl ; 61(4): e202113857, 2022 01 21.

Article in En | MEDLINE | ID: mdl-34825756

Subject(s)

Bismuth/pharmacology; Peptide Hydrolases/metabolism; Peptides, Cyclic/pharmacology; Protease Inhibitors/pharmacology; Bismuth/chemistry; Dose-Response Relationship, Drug; Peptides, Cyclic/chemical synthesis; Peptides, Cyclic/chemistry; Protease Inhibitors/chemical synthesis; Protease Inhibitors/chemistry; Protein Conformation; West Nile virus/enzymology; Zika Virus/enzymology

Key words

Bicycles; Bismuth; Inhibitors; Macrocyclization; Peptides

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Peptides, Cyclic / Protease Inhibitors / Bismuth Language: En Journal: Angew Chem Int Ed Engl Year: 2022 Type: Article Affiliation country: Australia

Fulltext

XML

PubMed Links

Search on Google