Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and Swine.

Sapoznikov, Anita; Gal, Yoav; Evgy, Yentl; Aftalion, Moshe; Katalan, Shahaf; Sabo, Tamar; Kronman, Chanoch; Falach, Reut

Sapoznikov, Anita; Gal, Yoav; Evgy, Yentl; Aftalion, Moshe; Katalan, Shahaf; Sabo, Tamar; Kronman, Chanoch; Falach, Reut.

Affiliation

Sapoznikov A; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Gal Y; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Evgy Y; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Aftalion M; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Katalan S; Division of Medical Chemistry, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Sabo T; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Kronman C; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Falach R; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona 74100, Israel.

Int J Mol Sci ; 22(22)2021 Nov 16.

Article in En | MEDLINE | ID: mdl-34830227

Subject(s)

Endothelial Cells/drug effects; Glycocalyx/drug effects; Ricin/toxicity; Ricinus/chemistry; Animals; Antigens, CD/genetics; Antigens, CD/metabolism; Cadherins/genetics; Cadherins/metabolism; Dose-Response Relationship, Drug; Endothelial Cells/cytology; Endothelial Cells/metabolism; Female; Gene Expression/drug effects; Glycocalyx/chemistry; Glycocalyx/metabolism; Heparitin Sulfate/chemistry; Heparitin Sulfate/metabolism; Humans; Hyaluronic Acid/chemistry; Hyaluronic Acid/metabolism; Hydrolysis; Injections, Intramuscular; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Liver/drug effects; Liver/metabolism; Liver/pathology; Mice; Microcirculation/drug effects; Ricin/isolation & purification; Spleen/drug effects; Spleen/metabolism; Spleen/pathology; Swine; Syndecan-1/chemistry; Syndecan-1/metabolism; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

Key words

glycocalyx shedding; heparan sulfate; hyaluronic acid; intramuscular; microcirculation; ricin; syndecan-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Ricinus / Glycocalyx / Endothelial Cells Type of study: Prognostic_studies Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Israel

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