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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics.
Alvarez-Jimenez, Ricardo; Weerink, Maud A S; Hannivoort, Laura N; Su, Hong; Struys, Michel M R F; Loer, Stephan A; Colin, Pieter J.
Affiliation
  • Alvarez-Jimenez R; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Weerink MAS; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Hannivoort LN; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Su H; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Struys MMRF; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; the Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.
  • Loer SA; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Colin PJ; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Anesthesiology ; 136(2): 279-292, 2022 02 01.
Article in En | MEDLINE | ID: mdl-34851425
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Clearance Rate / Drug Delivery Systems / Nonlinear Dynamics / Dexmedetomidine / Models, Biological Type of study: Guideline / Prognostic_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Anesthesiology Year: 2022 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Clearance Rate / Drug Delivery Systems / Nonlinear Dynamics / Dexmedetomidine / Models, Biological Type of study: Guideline / Prognostic_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Anesthesiology Year: 2022 Type: Article Affiliation country: Netherlands