Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics.
Anesthesiology
; 136(2): 279-292, 2022 02 01.
Article
in En
| MEDLINE
| ID: mdl-34851425
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Metabolic Clearance Rate
/
Drug Delivery Systems
/
Nonlinear Dynamics
/
Dexmedetomidine
/
Models, Biological
Type of study:
Guideline
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Anesthesiology
Year:
2022
Type:
Article
Affiliation country:
Netherlands