Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.

Kondak, Constantin; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Klein, Jochen

Kondak, Constantin; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Klein, Jochen.

Affiliation

Kondak C; Institute of Medical Sciences, Translational Neuroscience, University of Aberdeen, Aberdeen, Scotland.
Riedel G; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt, Germany.
Harrington CR; Institute of Medical Sciences, Translational Neuroscience, University of Aberdeen, Aberdeen, Scotland.
Wischik CM; Institute of Medical Sciences, Translational Neuroscience, University of Aberdeen, Aberdeen, Scotland.
Klein J; TauRx Therapeutics Ltd, Aberdeen, Scotland.

J Neurochem ; 160(2): 172-184, 2022 01.

Article in En | MEDLINE | ID: mdl-34855998

Subject(s)

Hippocampus/drug effects; Memantine/pharmacology; Methylene Blue/analogs & derivatives; Rivastigmine/pharmacology; Signal Transduction/drug effects; Acetylcholine/metabolism; Acetylcholinesterase/metabolism; Animals; Cholinesterase Inhibitors/pharmacology; Dopamine Agents/pharmacology; Drug Interactions; Female; Hippocampus/metabolism; Methylene Blue/pharmacology; Mice; Mice, Transgenic

Key words

Alzheimer's disease; acetylcholine; hippocampus; hydromethylthionine; memantine; microdialysis; rivastigmine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Memantine / Rivastigmine / Hippocampus / Methylene Blue Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2022 Type: Article Affiliation country: United kingdom

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