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Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target.
Lohoff, Falk W; Clarke, Toni-Kim; Kaminsky, Zachary A; Walker, Rosie M; Bermingham, Mairead L; Jung, Jeesun; Morris, Stewart W; Rosoff, Daniel; Campbell, Archie; Barbu, Miruna; Charlet, Katrin; Adams, Mark; Lee, Jisoo; Howard, David M; O'Connell, Emma M; Whalley, Heather; Porteous, David J; McIntosh, Andrew M; Evans, Kathryn L.
Affiliation
  • Lohoff FW; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. falk.lohoff@nih.gov.
  • Clarke TK; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
  • Kaminsky ZA; Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada.
  • Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Bermingham ML; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Jung J; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
  • Morris SW; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Rosoff D; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
  • Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Barbu M; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
  • Charlet K; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
  • Adams M; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
  • Lee J; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
  • Howard DM; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
  • O'Connell EM; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Whalley H; Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
  • Porteous DJ; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
  • McIntosh AM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Evans KL; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Mol Psychiatry ; 27(3): 1754-1764, 2022 03.
Article in En | MEDLINE | ID: mdl-34857913
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amino Acid Transport System y/ / Alcoholism / Epigenome Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2022 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amino Acid Transport System y/ / Alcoholism / Epigenome Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2022 Type: Article Affiliation country: United States