Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes.

Johnson, Joshua L; Huang, Jiansheng; Rooney, Michael; Gu, Chungang

Johnson, Joshua L; Huang, Jiansheng; Rooney, Michael; Gu, Chungang.

Affiliation

Johnson JL; Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA.
Huang J; Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA.
Rooney M; Clinical Pharmacology and Pharmacometrics, Biogen Inc., Cambridge, MA, USA.
Gu C; Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA.

Xenobiotica ; 52(2): 105-112, 2022 Feb.

Article in En | MEDLINE | ID: mdl-34904522

Subject(s)

Carboxylesterase; Microsomes, Liver; Carboxylesterase/metabolism; Carboxylic Ester Hydrolases/metabolism; Humans; Hydrogen-Ion Concentration; Hydrolysis; Liver/metabolism; Microsomes, Liver/metabolism; Phenyl Ethers; Proline/analogs & derivatives

Key words

CES1; Carboxylesterase; basic substrate; human liver microsomes; hydrolysis; neutral form; optimal pH; pH dependence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Carboxylesterase Limits: Humans Language: En Journal: Xenobiotica Year: 2022 Type: Article Affiliation country: United States

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