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TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
Shakiba, Mojdeh; Zumbo, Paul; Espinosa-Carrasco, Gabriel; Menocal, Laura; Dündar, Friederike; Carson, Sandra E; Bruno, Emmanuel M; Sanchez-Rivera, Francisco J; Lowe, Scott W; Camara, Steven; Koche, Richard P; Reuter, Vincent P; Socci, Nicholas D; Whitlock, Benjamin; Tamzalit, Fella; Huse, Morgan; Hellmann, Matthew D; Wells, Daniel K; Defranoux, Nadine A; Betel, Doron; Philip, Mary; Schietinger, Andrea.
Affiliation
  • Shakiba M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Zumbo P; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.
  • Espinosa-Carrasco G; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.
  • Menocal L; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.
  • Dündar F; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Carson SE; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Bruno EM; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.
  • Sanchez-Rivera FJ; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.
  • Lowe SW; Department of Biochemistry, Cell and Molecular Biology, Weill Cornell Medicine, New York, NY.
  • Camara S; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Koche RP; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Reuter VP; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Socci ND; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Whitlock B; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Tamzalit F; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Huse M; Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Hellmann MD; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Wells DK; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Defranoux NA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Betel D; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY.
  • Philip M; Parker Institute for Cancer Immunotherapy, San Francisco, CA.
  • Schietinger A; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
J Exp Med ; 219(2)2022 02 07.
Article in En | MEDLINE | ID: mdl-34935874
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Signal Transduction / T-Lymphocyte Subsets / Tumor Escape / Neoplasms Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Signal Transduction / T-Lymphocyte Subsets / Tumor Escape / Neoplasms Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2022 Type: Article