Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.

Munjal, Akankshi; Hannezo, Edouard; Tsai, Tony Y-C; Mitchison, Timothy J; Megason, Sean G

Munjal, Akankshi; Hannezo, Edouard; Tsai, Tony Y-C; Mitchison, Timothy J; Megason, Sean G.

Affiliation

Munjal A; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: akankshi.munjal@duke.edu.
Hannezo E; Institute of Science and Technology, Am Campus 1, 3400 Klosterneuburg, Austria.
Tsai TY; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Mitchison TJ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Megason SG; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: megason@hms.harvard.edu.

Cell ; 184(26): 6313-6325.e18, 2021 12 22.

Article in En | MEDLINE | ID: mdl-34942099

Subject(s)

Extracellular Space/chemistry; Hyaluronic Acid/pharmacology; Morphogenesis; Organ Specificity; Pressure; Semicircular Canals/cytology; Semicircular Canals/embryology; Actomyosin/metabolism; Animals; Anisotropy; Behavior, Animal; Extracellular Matrix/metabolism; Hyaluronic Acid/biosynthesis; Models, Biological; Morphogenesis/drug effects; Organ Specificity/drug effects; Osmotic Pressure; Semicircular Canals/diagnostic imaging; Stereotyped Behavior; Zebrafish/embryology; Zebrafish Proteins/metabolism

Key words

ECM; actomyosin; cadherin; hyaluronan; hyaluronic acid; hydraulics; inner ear; semicircular canals; tissue morphogenesis; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organ Specificity / Pressure / Semicircular Canals / Extracellular Space / Hyaluronic Acid / Morphogenesis Limits: Animals Language: En Journal: Cell Year: 2021 Type: Article

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