Management of oropharyngeal squamous cell carcinoma.

Grégoire, V; Giraud, P; Vieillevigne, L; Maingon, P

Grégoire, V; Giraud, P; Vieillevigne, L; Maingon, P.

Affiliation

Grégoire V; Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69373 Lyon, France. Electronic address: vincent.gregoire@lyon.unicancer.fr.
Giraud P; Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, université de Paris, 20, rue Leblanc, 75015 Paris, France.
Vieillevigne L; Unité de physique médicale, institut Claudius-Regaud, Institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France.
Maingon P; Département de radiothérapie, Sorbonne Université, groupe hospitalier La Pitié-Salpêtrière, Assistance publique-hôpitaux de Paris, 75013 Paris, France.

Cancer Radiother ; 26(1-2): 174-188, 2022.

Article in En | MEDLINE | ID: mdl-34953693

ABSTRACT

ABSTRACT

This article reviews the various treatment options, by primary or postoperative external radiotherapy and by brachytherapy for the p16-negative oropharyngeal squamous cell carcinoma. Dose levels, fractionation and association with systemic treatments are presented. The need for neck node dissection post local treatment is discussed, as well as specificities for the management of p16-positive tumours. Guidelines for target volume selection and delineation are thoroughly elaborated. Last, the management by radiotherapy of locoregional recurrences is discussed.

Subject(s)

Oropharyngeal Neoplasms/radiotherapy; Squamous Cell Carcinoma of Head and Neck/radiotherapy; Brachytherapy/methods; Cyclin-Dependent Kinase Inhibitor p16/metabolism; Dose Fractionation, Radiation; France; Humans; Induction Chemotherapy/methods; Neck Dissection; Neoplasm Recurrence, Local/radiotherapy; Neoplasm Recurrence, Local/surgery; Oropharyngeal Neoplasms/diagnostic imaging; Oropharyngeal Neoplasms/pathology; Oropharyngeal Neoplasms/surgery; Radiation Oncology; Retreatment; Societies, Medical; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging; Squamous Cell Carcinoma of Head and Neck/pathology; Squamous Cell Carcinoma of Head and Neck/surgery

Key words

Brachytherapy; Chimioradiothérapie concomitante; Concomitant chemoradiotherapy; Curiethérapie; French society for radiation oncology; Guidelines; Oropharyngeal tumours; P16-positive tumor; Radiation therapy; Radiothérapie; Recommandations; Société française de radiothérapie oncologique; Tumeur de l'oropharynx; Tumeur p16-positive; VMAT

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oropharyngeal Neoplasms / Squamous Cell Carcinoma of Head and Neck Type of study: Guideline Limits: Humans Country/Region as subject: Europa Language: En Journal: Cancer Radiother Journal subject: NEOPLASIAS / RADIOTERAPIA Year: 2022 Type: Article

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