Off-target inhibition of NGLY1 by the polycaspase inhibitor Z-VAD-fmk induces cellular autophagy.

Needs, Sarah H; Bootman, Martin D; Grotzke, Jeff E; Kramer, Holger B; Allman, Sarah A

Needs, Sarah H; Bootman, Martin D; Grotzke, Jeff E; Kramer, Holger B; Allman, Sarah A.

Affiliation

Needs SH; School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Bootman MD; Reading School of Pharmacy, University of Reading, UK.
Grotzke JE; School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Kramer HB; Yale University School of Medicine, New Haven, CT, USA.
Allman SA; Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

FEBS J ; 289(11): 3115-3131, 2022 06.

Article in En | MEDLINE | ID: mdl-34995415

Subject(s)

Fibroblasts; Proteomics; Animals; Autophagy; Caspases; Fibroblasts/metabolism; HEK293 Cells; Humans; Mice; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/chemistry; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/genetics; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/metabolism; Peptides/metabolism

Key words

NGLY1; Peptide: N-glycanase 1; Z-VAD-fmk; autophagosome proteomics; autophagy

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Fibroblasts Limits: Animals / Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2022 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google