Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models.

Liao, Minru; Xie, Qiang; Zhao, Yuqian; Yang, Chengcan; Lin, Congcong; Wang, Guan; Liu, Bo; Zhu, Lingjuan

Liao, Minru; Xie, Qiang; Zhao, Yuqian; Yang, Chengcan; Lin, Congcong; Wang, Guan; Liu, Bo; Zhu, Lingjuan.

Affiliation

Liao M; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xie Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhao Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110
Yang C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Lin C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang G; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: guan8079@163.com.
Liu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: liubo2400@163.com.
Zhu L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110

Pharmacol Res ; 176: 106077, 2022 02.

Article in En | MEDLINE | ID: mdl-35026404

Subject(s)

Chlorogenic Acid/analogs & derivatives; Coumaric Acids/therapeutic use; Drugs, Chinese Herbal; Heart Failure/drug therapy; Trisaccharides/therapeutic use; Animals; Apoptosis/drug effects; Autophagy/drug effects; Cell Line; Cell Survival/drug effects; Chlorogenic Acid/pharmacology; Chlorogenic Acid/therapeutic use; Coumaric Acids/pharmacology; Cyclic Nucleotide Phosphodiesterases, Type 5/genetics; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism; Disease Models, Animal; Heart Failure/chemically induced; Heart Failure/metabolism; Heart Failure/pathology; Isoproterenol; Male; Myoblasts/drug effects; Myocardium/metabolism; Myocardium/pathology; NADPH Oxidase 4/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Rats, Sprague-Dawley; Signal Transduction/drug effects; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; Trisaccharides/pharmacology

Key words

3,5-Dicaffeoylquinic acid (3,5-DiCQA); Angoriside C (AC); Apoptosis; Autophagy; Inflammation; Main active component; PDE5A; Si-Miao-Yong-An decoction (SMYAD); TLR4

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trisaccharides / Drugs, Chinese Herbal / Chlorogenic Acid / Coumaric Acids / Heart Failure Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2022 Type: Article Affiliation country: China

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