High Level Forebrain Expression of Active Tau Kinase p38Î³ Exacerbates Cognitive Dysfunction in Aged APP-transgenic Alzheimer's Mice.

Asih, Prita R; Stefanoska, Kristie; Prikas, Emmanuel; Ittner, Arne

Asih, Prita R; Stefanoska, Kristie; Prikas, Emmanuel; Ittner, Arne.

Affiliation

Asih PR; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Stefanoska K; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Prikas E; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Ittner A; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia. Electronic address: arne.ittner@flinders.edu.au.

Neuroscience ; 484: 53-65, 2022 02 21.

Article in En | MEDLINE | ID: mdl-35031398

Subject(s)

Alzheimer Disease; Cognitive Dysfunction; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Prosencephalon/metabolism; tau Proteins/genetics; tau Proteins/metabolism

Key words

Alzheimer's disease; gene therapy; microtubule-associated protein tau; mitogen-activated protein kinase; neuroprotection; p38

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Cognitive Dysfunction Limits: Animals Language: En Journal: Neuroscience Year: 2022 Type: Article Affiliation country: Australia

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