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The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Domizio, Jeremy Di; Gulen, Muhammet F; Saidoune, Fanny; Thacker, Vivek V; Yatim, Ahmad; Sharma, Kunal; Nass, Théo; Guenova, Emmanuella; Schaller, Martin; Conrad, Curdin; Goepfert, Christine; de Leval, Laurence; Garnier, Christophe von; Berezowska, Sabina; Dubois, Anaëlle; Gilliet, Michel; Ablasser, Andrea.
Affiliation
  • Domizio JD; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Gulen MF; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Saidoune F; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Thacker VV; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Yatim A; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Sharma K; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Nass T; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Guenova E; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Schaller M; University Department of Dermatology, Eberhard Karls University of Tübingen, Tübingen, Germany.
  • Conrad C; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Goepfert C; Institute of Animal Pathology, COMPATH, University of Bern, Bern, Switzerland.
  • de Leval L; Histology Core Facility, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Garnier CV; Institute of Pathology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Berezowska S; Division of Pulmonology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Dubois A; Institute of Pathology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
  • Gilliet M; Biological Electron Microscopy Facility, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
  • Ablasser A; Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland. michel.gilliet@chuv.ch.
Nature ; 603(7899): 145-151, 2022 03.
Article in En | MEDLINE | ID: mdl-35045565
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / SARS-CoV-2 / COVID-19 / Membrane Proteins / Nucleotidyltransferases Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / SARS-CoV-2 / COVID-19 / Membrane Proteins / Nucleotidyltransferases Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: Switzerland