Mechanistic insight into the destabilization of p53TD tetramer by cancer-related R337H mutation: a molecular dynamics study.

Yu, Yawei; Dong, Xuewei; Tang, Yiming; Li, Le; Wei, Guanghong

Yu, Yawei; Dong, Xuewei; Tang, Yiming; Li, Le; Wei, Guanghong.

Affiliation

Yu Y; Department of physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China. ghwei@fudan.edu.cn.
Dong X; Department of physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China. ghwei@fudan.edu.cn.
Tang Y; Department of physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China. ghwei@fudan.edu.cn.
Li L; Department of physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China. ghwei@fudan.edu.cn.
Wei G; Department of physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China. ghwei@fudan.edu.cn.

Phys Chem Chem Phys ; 24(8): 5199-5210, 2022 Feb 23.

Article in En | MEDLINE | ID: mdl-35166747

Subject(s)

Neoplasms; Tumor Suppressor Protein p53/chemistry; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation; Neoplasms/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Neoplasms Limits: Humans Language: En Journal: Phys Chem Chem Phys Journal subject: BIOFISICA / QUIMICA Year: 2022 Type: Article

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