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Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
Jouffe, Céline; Weger, Benjamin D; Martin, Eva; Atger, Florian; Weger, Meltem; Gobet, Cédric; Ramnath, Divya; Charpagne, Aline; Morin-Rivron, Delphine; Powell, Elizabeth E; Sweet, Matthew J; Masoodi, Mojgan; Uhlenhaut, N Henriette; Gachon, Frédéric.
Affiliation
  • Jouffe C; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Weger BD; Department of Pharmacology and Toxicology, University of Lausanne, CH-1011 Lausanne, Switzerland.
  • Martin E; Helmholtz Diabetes Center, Helmholtz Zentrum München, DE-85764 Neuherberg, Germany.
  • Atger F; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Weger M; Institute for Molecular Bioscience, The University of Queensland, St. Lucia QLD 4072, Australia.
  • Gobet C; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Ramnath D; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Charpagne A; Department of Pharmacology and Toxicology, University of Lausanne, CH-1011 Lausanne, Switzerland.
  • Morin-Rivron D; Institute for Molecular Bioscience, The University of Queensland, St. Lucia QLD 4072, Australia.
  • Powell EE; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Sweet MJ; School of Life Sciences, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Masoodi M; Institute for Molecular Bioscience, The University of Queensland, St. Lucia QLD 4072, Australia.
  • Uhlenhaut NH; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
  • Gachon F; Nestlé Research, Société des Produits Nestlé, CH-1015 Lausanne, Switzerland.
Proc Natl Acad Sci U S A ; 119(10): e2200083119, 2022 03 08.
Article in En | MEDLINE | ID: mdl-35238641
ABSTRACT
SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. Here, we show that, in both humans and mice, the pathogenesis of NAFLD is associated with the disruption of the circadian clock combined with perturbations of the growth hormone and sex hormone pathways. However, while this condition protects mice from the development of fibrosis and insulin resistance, it correlates with increased fibrosis in humans. This suggests that the perturbation of the circadian clock and its associated disruption of the growth hormone and sex hormone pathways are critical for the pathogenesis of metabolic and liver diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / ARNTL Transcription Factors / Circadian Clocks / Non-alcoholic Fatty Liver Disease Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / ARNTL Transcription Factors / Circadian Clocks / Non-alcoholic Fatty Liver Disease Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Switzerland