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Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization.
Shan, Sisi; Luo, Shitong; Yang, Ziqing; Hong, Junxian; Su, Yufeng; Ding, Fan; Fu, Lili; Li, Chenyu; Chen, Peng; Ma, Jianzhu; Shi, Xuanling; Zhang, Qi; Berger, Bonnie; Zhang, Linqi; Peng, Jian.
Affiliation
  • Shan S; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Luo S; HeliXon Limited, Beijing 100084, China.
  • Yang Z; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Hong J; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Su Y; Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, IL 61822.
  • Ding F; HeliXon Limited, Beijing 100084, China.
  • Fu L; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Li C; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Chen P; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Ma J; HeliXon Limited, Beijing 100084, China.
  • Shi X; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Zhang Q; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Berger B; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Zhang L; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Peng J; NexVac Research Center, Comprehensive AIDS Research Center, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Proc Natl Acad Sci U S A ; 119(11): e2122954119, 2022 03 15.
Article in En | MEDLINE | ID: mdl-35238654
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Broadly Neutralizing Antibodies / SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Broadly Neutralizing Antibodies / SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China