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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.
Olsen, Sarah Naomi; Godfrey, Laura; Healy, James P; Choi, Yoolim A; Kai, Yan; Hatton, Charles; Perner, Florian; Haarer, Elena L; Nabet, Behnam; Yuan, Guo-Cheng; Armstrong, Scott A.
Affiliation
  • Olsen SN; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Godfrey L; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Healy JP; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Choi YA; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Kai Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Perner F; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; Internal Medicine C, University Medical Center Greifswald, 17475 Greifswald, Germany.
  • Haarer EL; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Nabet B; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Yuan GC; Department of Genetics and Genomic Sciences and Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address: scott_armstrong@dfci.harvard.edu.
Mol Cell ; 82(6): 1140-1155.e11, 2022 03 17.
Article in En | MEDLINE | ID: mdl-35245435
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Myeloid-Lymphoid Leukemia Protein Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Myeloid-Lymphoid Leukemia Protein Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: United States