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Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction.
De Bei, Omar; Marchetti, Marialaura; Ronda, Luca; Gianquinto, Eleonora; Lazzarato, Loretta; Chirgadze, Dimitri Y; Hardwick, Steven W; Cooper, Lee R; Spyrakis, Francesca; Luisi, Ben F; Campanini, Barbara; Bettati, Stefano.
Affiliation
  • De Bei O; Interdepartmental Center Biopharmanet-TEC, University of Parma, Parma 43124, Italy.
  • Marchetti M; Interdepartmental Center Biopharmanet-TEC, University of Parma, Parma 43124, Italy.
  • Ronda L; Department of Medicine and Surgery, University of Parma, Parma 43126, Italy.
  • Gianquinto E; Interdepartmental Center Biopharmanet-TEC, University of Parma, Parma 43124, Italy.
  • Lazzarato L; Department of Medicine and Surgery, University of Parma, Parma 43126, Italy.
  • Chirgadze DY; Institute of Biophysics, National Research Council, Pisa 56124, Italy.
  • Hardwick SW; Department of Drug Science and Technology, University of Turin, Turin 10125, Italy.
  • Cooper LR; Department of Drug Science and Technology, University of Turin, Turin 10125, Italy.
  • Spyrakis F; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
  • Luisi BF; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
  • Campanini B; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
  • Bettati S; Department of Drug Science and Technology, University of Turin, Turin 10125, Italy.
Proc Natl Acad Sci U S A ; 119(14): e2116708119, 2022 04 05.
Article in En | MEDLINE | ID: mdl-35357971
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemoglobins / Cation Transport Proteins / Heme Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemoglobins / Cation Transport Proteins / Heme Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: Italy