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Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.
Koh, Eun-Ik; Oluoch, Peter O; Ruecker, Nadine; Proulx, Megan K; Soni, Vijay; Murphy, Kenan C; Papavinasasundaram, Kadamba; Reames, Charlotte J; Trujillo, Carolina; Zaveri, Anisha; Zimmerman, Matthew D; Aslebagh, Roshanak; Baker, Richard E; Shaffer, Scott A; Guinn, Kristine M; Fitzgerald, Michael; Dartois, Véronique; Ehrt, Sabine; Hung, Deborah T; Ioerger, Thomas R; Rubin, Eric J; Rhee, Kyu Y; Schnappinger, Dirk; Sassetti, Christopher M.
Affiliation
  • Koh EI; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Oluoch PO; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Ruecker N; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.
  • Proulx MK; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Soni V; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.
  • Murphy KC; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Papavinasasundaram K; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Reames CJ; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Trujillo C; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.
  • Zaveri A; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.
  • Zimmerman MD; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
  • Aslebagh R; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655.
  • Baker RE; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545.
  • Shaffer SA; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655.
  • Guinn KM; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655.
  • Fitzgerald M; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545.
  • Dartois V; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
  • Ehrt S; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.
  • Hung DT; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
  • Ioerger TR; Department of Medical Sciences, Hackensack School of Medicine, Nutley, NJ 07110.
  • Rubin EJ; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.
  • Rhee KY; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.
  • Schnappinger D; Center for Computation and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.
  • Sassetti CM; Department of Genetics, Harvard Medical School, Boston, MA 02114.
Proc Natl Acad Sci U S A ; 119(15): e2201632119, 2022 04 12.
Article in En | MEDLINE | ID: mdl-35380903
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon / Cell Wall / Drug Interactions / Gene-Environment Interaction / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon / Cell Wall / Drug Interactions / Gene-Environment Interaction / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article