Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway.

Saxena, Nandita; Dhaked, Ram Kumar; Nagar, D P

Saxena, Nandita; Dhaked, Ram Kumar; Nagar, D P.

Affiliation

Saxena N; Division of Pharmacology & Toxicology, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India. Electronic address: saxenanandita@gmail.com.
Dhaked RK; Biotechnology Division, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India.
Nagar DP; Division of Pharmacology & Toxicology, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India.

Environ Toxicol Pharmacol ; 93: 103868, 2022 Jul.

Article in En | MEDLINE | ID: mdl-35504510

Subject(s)

Abrin; Chemical and Drug Induced Liver Injury; Silybin; fas Receptor; Abrin/toxicity; Animals; Antioxidants/pharmacology; Chemical and Drug Induced Liver Injury/drug therapy; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/prevention & control; Drug Interactions; Inflammation/chemically induced; Inflammation/drug therapy; Mice; Oxidative Stress/drug effects; Signal Transduction/drug effects; Silybin/pharmacology; fas Receptor/antagonists & inhibitors; fas Receptor/metabolism

Key words

Abrin; Fas Pathway; Ricin, Ribosomal inhibiting protein, Silibinin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fas Receptor / Abrin / Chemical and Drug Induced Liver Injury / Silybin Limits: Animals Language: En Journal: Environ Toxicol Pharmacol Year: 2022 Type: Article

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