Derivatives of sarcodonin A isolated from Sarcodon scabrosus reversed LPS-induced M1 polarization in microglia through MAPK/NF-&#954;B pathway.

Cao, Chen-Yu; Yang, Ying-Xiang; Xie, Zhao; Chen, Xin; Shi, Xin-Wei; Yin, Xia; Gao, Jin-Ming

Derivatives of sarcodonin A isolated from Sarcodon scabrosus reversed LPS-induced M1 polarization in microglia through MAPK/NF-κB pathway.

Cao, Chen-Yu; Yang, Ying-Xiang; Xie, Zhao; Chen, Xin; Shi, Xin-Wei; Yin, Xia; Gao, Jin-Ming.

Affiliation

Cao CY; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: caocy@nwsuaf.edu.cn.
Yang YX; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Xie Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: chenxin1888@nwsuaf.edu.cn.
Shi XW; Xi'an Botanical Garden, Institute of Botany of Shaanxi Province, Xi'an 710061, Shanxi, China.
Yin X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Gao JM; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: jinminggao@nwsuaf.edu.cn.

Bioorg Chem ; 125: 105854, 2022 08.

Article in En | MEDLINE | ID: mdl-35597110

Subject(s)

Microglia; NF-kappa B; Basidiomycota; Lipopolysaccharides/metabolism; Lipopolysaccharides/pharmacology; Molecular Docking Simulation; NF-kappa B/metabolism; RNA, Messenger/metabolism; Terpenes

Key words

Cyathane diterpene; MAPK; Microglia M1 polarization; NF-κB; Sarcodonin A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Microglia Type of study: Prognostic_studies Language: En Journal: Bioorg Chem Year: 2022 Type: Article

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