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Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-ß.
Cespedes, Marcela; Jacobs, Kelly R; Maruff, Paul; Rembach, Alan; Fowler, Christopher J; Trounson, Brett; Pertile, Kelly K; Rumble, Rebecca L; Rainey-Smith, Stephanie R; Rowe, Christopher C; Villemagne, Victor L; Bourgeat, Pierrick; Lim, Chai K; Chatterjee, Pratishtha; Martins, Ralph N; Ittner, Arne; Masters, Colin L; Doecke, James D; Guillemin, Gilles J; Lovejoy, David B.
Affiliation
  • Cespedes M; Australian eHealth Research Centre, CSIRO, Herston, Queensland, Australia.
  • Jacobs KR; Macquarie University Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Maruff P; Cogstate Limited, Melbourne, Victoria, Australia.
  • Rembach A; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Fowler CJ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Trounson B; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Pertile KK; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Rumble RL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Rainey-Smith SR; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Rowe CC; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.
  • Villemagne VL; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia; The University of Pittsburgh, Pittsburgh, USA.
  • Bourgeat P; Australian eHealth Research Centre, CSIRO, Herston, Queensland, Australia.
  • Lim CK; Macquarie University Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Chatterjee P; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Au
  • Martins RN; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Au
  • Ittner A; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Masters CL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • Doecke JD; Australian eHealth Research Centre, CSIRO, Herston, Queensland, Australia. Electronic address: james.doecke@csiro.au.
  • Guillemin GJ; Macquarie University Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia. Electronic address: gilles.guillemin@mq.edu.au.
  • Lovejoy DB; Macquarie University Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia. Electronic address: david.lovejoy@mq.edu.au.
Neurobiol Dis ; 171: 105783, 2022 09.
Article in En | MEDLINE | ID: mdl-35675895
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Alzheimer Disease / Cognitive Dysfunction Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Oceania Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2022 Type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Alzheimer Disease / Cognitive Dysfunction Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Oceania Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2022 Type: Article Affiliation country: Australia