<i>Alpinia katsumadai Hayata</i> induces growth inhibition and autophagy­related apoptosis by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways in cancer cells.

An, Weixiao; Zhang, Yuxi; Lai, Honglin; Zhang, Yangyang; Zhang, Hongmei; Zhao, Ge; Liu, Minghua; Li, Yang; Lin, Xiukun; Cao, Shousong

Alpinia katsumadai Hayata induces growth inhibition and autophagyrelated apoptosis by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways in cancer cells.

An, Weixiao; Zhang, Yuxi; Lai, Honglin; Zhang, Yangyang; Zhang, Hongmei; Zhao, Ge; Liu, Minghua; Li, Yang; Lin, Xiukun; Cao, Shousong.

Affiliation

An W; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Zhang Y; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Lai H; Department of Pharmacy, Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Zhang Y; Department of Pharmacy, Dongying Hospital of Traditional Chinese Medicine, Dongying, Shandong 257055, P.R. China.
Zhang H; Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong 276801, P.R. China.
Zhao G; Department of Pharmacology, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China.
Liu M; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Li Y; Department of International Trade, School of International Traded and Economics, University of International Business and Economics, Beijing 100029, P.R. China.
Lin X; Delisi Group Co. Ltd., Zhucheng, Shandong 262200, P.R. China.
Cao S; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Oncol Rep ; 48(2)2022 08.

Article in En | MEDLINE | ID: mdl-35730618

Subject(s)

Alpinia; Lung Neoplasms; AMP-Activated Protein Kinases/metabolism; Alpinia/metabolism; Animals; Apoptosis; Autophagy; Caspase 3/metabolism; Caspase 8/metabolism; Caspase 9/metabolism; Cell Line, Tumor; Humans; Lung Neoplasms/pathology; Mice; Mice, Nude; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Signal Transduction; TOR Serine-Threonine Kinases/metabolism

Key words

Alpinia katsumadai Hayata; adenosine 5'monophosphateactivated protein kinase; apoptosis; autophagy; serinethreonine kinase/mammalian target of rapamycin/70kDa ribosomal protein S6 kinase signaling pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpinia / Lung Neoplasms Limits: Animals / Humans Language: En Journal: Oncol Rep Journal subject: NEOPLASIAS Year: 2022 Type: Article

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