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Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Xu, Yan-Ran; Shi, Meng-Ling; Zhang, Yu; Kong, Na; Wang, Cong; Xiao, Yi-Feng; Du, Shi-Shen; Zhu, Qi-Yun; Lei, Cao-Qi.
Affiliation
  • Xu YR; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Shi ML; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Zhang Y; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
  • Kong N; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Wang C; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Xiao YF; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
  • Du SS; Tongji School of Pharmacy, Huazhong University of Science & Technology, Wuhan 430030, China.
  • Zhu QY; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Lei CQ; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Proc Natl Acad Sci U S A ; 119(26): e2122805119, 2022 06 28.
Article in En | MEDLINE | ID: mdl-35733260
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Virus Infections / RNA Viruses / Tankyrases / Ubiquitin-Protein Ligases / Adaptor Proteins, Signal Transducing / Immunity, Innate Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Virus Infections / RNA Viruses / Tankyrases / Ubiquitin-Protein Ligases / Adaptor Proteins, Signal Transducing / Immunity, Innate Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Type: Article Affiliation country: China