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Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase.
Sourimant, Julien; Lieber, Carolin M; Yoon, Jeong-Joong; Toots, Mart; Govindarajan, Mugunthan; Udumula, Venkata; Sakamoto, Kaori; Natchus, Michael G; Patti, Joseph; Vernachio, John; Plemper, Richard K.
Affiliation
  • Sourimant J; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Lieber CM; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Yoon JJ; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Toots M; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Govindarajan M; Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
  • Udumula V; Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
  • Sakamoto K; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
  • Natchus MG; Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
  • Patti J; Aviragen Therapeutics Inc, Alpharetta, GA 30009, USA.
  • Vernachio J; Aviragen Therapeutics Inc, Alpharetta, GA 30009, USA.
  • Plemper RK; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Sci Adv ; 8(25): eabo2236, 2022 06 24.
Article in En | MEDLINE | ID: mdl-35749502
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2022 Type: Article Affiliation country: United States
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2022 Type: Article Affiliation country: United States