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Spontaneous NLRP3 inflammasome-driven IL-1-ß secretion is induced in severe COVID-19 patients and responds to anakinra treatment.
Bertoni, Arinna; Penco, Federica; Mollica, Hilaria; Bocca, Paola; Prigione, Ignazia; Corcione, Anna; Cangelosi, Davide; Schena, Francesca; Del Zotto, Genny; Amaro, Adriana; Paladino, Noemi; Pontali, Emanuele; Feasi, Marcello; Signa, Sara; Bustaffa, Marta; Caorsi, Roberta; Palmeri, Serena; Contini, Paola; De Palma, Raffaele; Pfeffer, Ulrich; Uva, Paolo; Rubartelli, Anna; Gattorno, Marco; Volpi, Stefano.
Affiliation
  • Bertoni A; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy; DINOGMI, Università degli Studi di Genova, Genova, Italy.
  • Penco F; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Mollica H; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy; DINOGMI, Università degli Studi di Genova, Genova, Italy.
  • Bocca P; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Prigione I; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Corcione A; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Cangelosi D; Clinical Bioinformatics Unit and Diagnostics, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Schena F; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Del Zotto G; Department of Research and Diagnostics, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Amaro A; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Paladino N; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Pontali E; Ente Ospedaliero Ospedale Galliera, Genova, Italy.
  • Feasi M; Ente Ospedaliero Ospedale Galliera, Genova, Italy.
  • Signa S; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy; DINOGMI, Università degli Studi di Genova, Genova, Italy.
  • Bustaffa M; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Caorsi R; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Palmeri S; DINOGMI, Università degli Studi di Genova, Genova, Italy.
  • Contini P; Department of Internal Medicine, University of Genoa and IRCCS IST-Ospedale San Martino, Genova, Italy.
  • De Palma R; Department of Internal Medicine, University of Genoa and IRCCS IST-Ospedale San Martino, Genova, Italy.
  • Pfeffer U; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Uva P; Clinical Bioinformatics Unit and Diagnostics, IRCCS Istituto Giannina Gaslini, Genova, Italy; Italian Institute of Technology, Genova, Italy.
  • Rubartelli A; Istituto Giannina Gaslini, Genova, Italy.
  • Gattorno M; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy. Electronic address: marcogattorno@gaslini.org.
  • Volpi S; UOSD Centro per le Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy; DINOGMI, Università degli Studi di Genova, Genova, Italy. Electronic address: stefanovolpi@gaslini.org.
J Allergy Clin Immunol ; 150(4): 796-805, 2022 10.
Article in En | MEDLINE | ID: mdl-35835255
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / COVID-19 Drug Treatment Limits: Humans Language: En Journal: J Allergy Clin Immunol Year: 2022 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / COVID-19 Drug Treatment Limits: Humans Language: En Journal: J Allergy Clin Immunol Year: 2022 Type: Article Affiliation country: Italy