Host Range Expansion of <i>Shigella</i> Phage Sf6 Evolves through Point Mutations in the Tailspike.

Subramanian, Sundharraman; Dover, John A; Parent, Kristin N; Doore, Sarah M

Host Range Expansion of Shigella Phage Sf6 Evolves through Point Mutations in the Tailspike.

Subramanian, Sundharraman; Dover, John A; Parent, Kristin N; Doore, Sarah M.

Affiliation

Subramanian S; Department of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Dover JA; Department of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Parent KN; Department of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Doore SM; Department of Biochemistry and Molecular Biology, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.

J Virol ; 96(16): e0092922, 2022 08 24.

Article in En | MEDLINE | ID: mdl-35894604

Subject(s)

Bacteriophages/genetics; Glycoside Hydrolases/genetics; Point Mutation; Shigella flexneri/virology; Viral Tail Proteins/genetics; Host Specificity; Lipopolysaccharide Receptors/metabolism; Lipopolysaccharides/metabolism; O Antigens/chemistry; O Antigens/genetics; O Antigens/metabolism

Key words

bacteriophage evolution; bacteriophages; experimental evolution; protein structure-function; structural biology; virus-host interactions

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shigella flexneri / Bacteriophages / Viral Tail Proteins / Point Mutation / Glycoside Hydrolases Type of study: Prognostic_studies Language: En Journal: J Virol Year: 2022 Type: Article Affiliation country: United States

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