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α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention.
Islam, Sidra; Do, Michael T; Frank, Brett S; Hom, Grant L; Wheeler, Samuel; Fujioka, Hisashi; Wang, Benlian; Minocha, Geeta; Sell, David R; Fan, Xingjun; Lampi, Kirsten J; Monnier, Vincent M.
Affiliation
  • Islam S; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Do MT; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Frank BS; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Hom GL; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Wheeler S; Department of Integrative Biosciences, Oregon Health & Sciences University, Portland, Oregon, USA.
  • Fujioka H; Cryo-EM Core Facility, School of Medicine, Case Western Reserve University, Case Western Reserve University, Cleveland, Ohio, USA.
  • Wang B; Center for Proteomics and Bioinformatics, Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, USA.
  • Minocha G; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Sell DR; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Fan X; Department of Cell Biology and Anatomy, Augusta University, Georgia, Georgia, USA.
  • Lampi KJ; Department of Integrative Biosciences, Oregon Health & Sciences University, Portland, Oregon, USA.
  • Monnier VM; Department of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA; Department of Biochemistry, Case Western Reserve University, Cleveland Ohio, USA. Electronic address: vmm3@cwru.edu.
J Biol Chem ; 298(10): 102417, 2022 10.
Article in En | MEDLINE | ID: mdl-36037967
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salicylanilides / Cataract / Molecular Chaperones / Alpha-Crystallins / Gamma-Crystallins / Biomimetic Materials / Xanthones / Protein Aggregation, Pathological / Lens, Crystalline Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salicylanilides / Cataract / Molecular Chaperones / Alpha-Crystallins / Gamma-Crystallins / Biomimetic Materials / Xanthones / Protein Aggregation, Pathological / Lens, Crystalline Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Type: Article Affiliation country: United States