A flexible electronic strain sensor for the real-time monitoring of tumor regression.
Sci Adv
; 8(37): eabn6550, 2022 09 16.
Article
in En
| MEDLINE
| ID: mdl-36112679
ABSTRACT
Assessing the efficacy of cancer therapeutics in mouse models is a critical step in treatment development. However, low-resolution measurement tools and small sample sizes make determining drug efficacy in vivo a difficult and time-intensive task. Here, we present a commercially scalable wearable electronic strain sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring the micrometer-scale progression or regression of subcutaneously implanted tumors at the minute time scale. In two in vivo cancer mouse models, our sensor discerned differences in tumor volume dynamics between drug- and vehicle-treated tumors within 5 hours following therapy initiation. These short-term regression measurements were validated through histology, and caliper and bioluminescence measurements taken over weeklong treatment periods demonstrated the correlation with longer-term treatment response. We anticipate that real-time tumor regression datasets could help expedite and automate the process of screening cancer therapies in vivo.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognition
/
Electronics
Limits:
Animals
Language:
En
Journal:
Sci Adv
Year:
2022
Type:
Article
Affiliation country:
United States