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Antibody targeting of E3 ubiquitin ligases for receptor degradation.
Marei, Hadir; Tsai, Wen-Ting K; Kee, Yee-Seir; Ruiz, Karen; He, Jieyan; Cox, Chris; Sun, Tao; Penikalapati, Sai; Dwivedi, Pankaj; Choi, Meena; Kan, David; Saenz-Lopez, Pablo; Dorighi, Kristel; Zhang, Pamela; Kschonsak, Yvonne T; Kljavin, Noelyn; Amin, Dhara; Kim, Ingrid; Mancini, Andrew G; Nguyen, Thao; Wang, Chunling; Janezic, Eric; Doan, Alexander; Mai, Elaine; Xi, Hongkang; Gu, Chen; Heinlein, Melanie; Biehs, Brian; Wu, Jia; Lehoux, Isabelle; Harris, Seth; Comps-Agrar, Laetitia; Seshasayee, Dhaya; de Sauvage, Frederic J; Grimmer, Matthew; Li, Jing; Agard, Nicholas J; de Sousa E Melo, Felipe.
Affiliation
  • Marei H; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Tsai WK; Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Kee YS; Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Ruiz K; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • He J; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Cox C; Discovery Immunology, Genentech Inc, South San Francisco, CA, USA.
  • Sun T; Molecular Biology, Genentech, South San Francisco, CA, USA.
  • Penikalapati S; Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Dwivedi P; Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Choi M; Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Kan D; Translational Oncology, Genentech, South San Francisco, CA, USA.
  • Saenz-Lopez P; Translational Oncology, Genentech, South San Francisco, CA, USA.
  • Dorighi K; Molecular Biology, Genentech, South San Francisco, CA, USA.
  • Zhang P; Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Kschonsak YT; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Kljavin N; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Amin D; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Kim I; Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Mancini AG; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Nguyen T; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Wang C; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Janezic E; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Doan A; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Mai E; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Xi H; Antibody discovery, Genentech, South San Francisco, CA, USA.
  • Gu C; Protein Chemistry, Genentech, South San Francisco, CA, USA.
  • Heinlein M; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Biehs B; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Wu J; Antibody discovery, Genentech, South San Francisco, CA, USA.
  • Lehoux I; Biomolecular Resources, Genentech, South San Francisco, CA, USA.
  • Harris S; Structural Biology, Genentech, South San Francisco, CA, USA.
  • Comps-Agrar L; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Seshasayee D; Antibody discovery, Genentech, South San Francisco, CA, USA.
  • de Sauvage FJ; Molecular Oncology, Genentech, South San Francisco, CA, USA.
  • Grimmer M; Discovery Oncology, Genentech, South San Francisco, CA, USA.
  • Li J; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
  • Agard NJ; Antibody Engineering, Genentech, South San Francisco, CA, USA. agardn@gene.com.
  • de Sousa E Melo F; Discovery Oncology, Genentech, South San Francisco, CA, USA. desousaf@gene.com.
Nature ; 610(7930): 182-189, 2022 10.
Article in En | MEDLINE | ID: mdl-36131013
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Proteolysis / Membrane Proteins / Antibodies / Antibody Specificity Limits: Animals Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Proteolysis / Membrane Proteins / Antibodies / Antibody Specificity Limits: Animals Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States