Superficial (nodular) thrombophlebitis as a heterogeneous entity with distinctive clinico-pathological aspects: Correlation with the underlying conditions.
J Eur Acad Dermatol Venereol
; 37(2): 436-442, 2023 Feb.
Article
in En
| MEDLINE
| ID: mdl-36178454
ABSTRACT
BACKGROUND:
Superficial (nodular) thrombophlebitis, referring to a thrombo-inflammatory disorder of dermal-subcutaneous veins, encompass a spectrum of nodular lesions often associated with inflammatory, infectious, neoplastic or thrombophilic diseases.OBJECTIVE:
We postulate that distinct clinico-pathological features may correlate with the underlying conditions.METHODS:
We conducted a retrospective monocentric study of all patients seen in our dermatology department for a superficial thrombophlebitis, completed with a literature review. Clinical and pathological data were extracted from the patient files and articles.RESULTS:
A total of 108 cases of superficial thrombophlebitis was analysed. Forty-five percent manifested as elongated nodules clearly evoking vascular involvement, while the other 55% were presenting as nodules or plaques. The elongated phenotype was strongly associated with malignancy or thrombophilia if a pure thrombosis was demonstrated histopathologically, while tuberculosis was the main underlying condition if a granulomatous vasculitis was present. Panniculitis-like lesions were mainly corresponding to erythema-nodosum-like lesions of Behçet's disease, characterized by the distinctive feature of thrombotic veins with an associated leukocytoclastic vasculitis.LIMITATIONS:
Retrospective design and risk of publication bias.CONCLUSION:
Superficial (nodular) thrombophlebitis is a heterogeneous entity with a distinct clinico-pathological presentation that strongly points to the nature of the underlying medical condition, thus guiding the medical workup.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombophlebitis
/
Tuberculosis
/
Panniculitis
/
Erythema Nodosum
Limits:
Humans
Language:
En
Journal:
J Eur Acad Dermatol Venereol
Journal subject:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Year:
2023
Type:
Article
Affiliation country:
France