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CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance.
Matsumura, Shigenobu; Miyakita, Motoki; Miyamori, Haruka; Kyo, Satomi; Ishikawa, Fuka; Sasaki, Tsutomu; Jinno, Tomoki; Tanaka, Jin; Fujita, Kotomi; Yokokawa, Takumi; Goto, Tsuyoshi; Momma, Keiko; Takenaka, Shigeo; Inoue, Kazuo.
Affiliation
  • Matsumura S; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Miyakita M; Department of Nutrition, Osaka Metropolitan University, Osaka, Japan.
  • Miyamori H; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Kyo S; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Ishikawa F; Department of Food and Nutrition, Kyoto Women's University, Kyoto, Japan.
  • Sasaki T; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Jinno T; Department of Neurology, Graduate School of Medicine, Osaka University, Osaka, Japan.
  • Tanaka J; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Fujita K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Yokokawa T; Department of Nutrition, Osaka Metropolitan University, Osaka, Japan.
  • Goto T; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Momma K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Takenaka S; Department of Food and Nutrition, Kyoto Women's University, Kyoto, Japan.
  • Inoue K; Department of Nutrition, Osaka Metropolitan University, Osaka, Japan.
FASEB J ; 36(12): e22645, 2022 12.
Article in En | MEDLINE | ID: mdl-36349991
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Receptor, Melanocortin, Type 4 Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Type: Article Affiliation country: Japan
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Receptor, Melanocortin, Type 4 Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Type: Article Affiliation country: Japan