Distinction of early complement classical and lectin pathway activation <i>via</i> quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.

Hurler, Lisa; Toonen, Erik J M; Kajdácsi, Erika; van Bree, Bregje; Brandwijk, Ricardo J M G E; de Bruin, Wieke; Lyons, Paul A; Bergamaschi, Laura; Sinkovits, György; Cervenak, László; Würzner, Reinhard; Prohászka, Zoltán

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.

Hurler, Lisa; Toonen, Erik J M; Kajdácsi, Erika; van Bree, Bregje; Brandwijk, Ricardo J M G E; de Bruin, Wieke; Lyons, Paul A; Bergamaschi, Laura; Sinkovits, György; Cervenak, László; Würzner, Reinhard; Prohászka, Zoltán.

Affiliation

Hurler L; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Toonen EJM; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Kajdácsi E; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
van Bree B; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Brandwijk RJMGE; Research and Development Department, Hycult Biotech, Uden, Netherlands.
de Bruin W; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom.
Bergamaschi L; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Sinkovits G; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Würzner R; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Prohászka Z; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.

Front Immunol ; 13: 1039765, 2022.

Article in En | MEDLINE | ID: mdl-36420270

Subject(s)

COVID-19; Mannose-Binding Protein-Associated Serine Proteases; Adult; Humans; Complement C1 Inhibitor Protein; Complement System Proteins; COVID-19/diagnosis; Lectins; Mannose-Binding Protein-Associated Serine Proteases/metabolism; Enzyme-Linked Immunosorbent Assay

Key words

C1-INH complexes; C1s/C1-INH complex; MASP-1/C1-INH complex; assay development and validation; classical pathway activation; early complement activation; lectin pathway activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mannose-Binding Protein-Associated Serine Proteases / COVID-19 Type of study: Diagnostic_studies Limits: Adult / Humans Language: En Journal: Front Immunol Year: 2022 Type: Article Affiliation country: Hungary

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