STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.

Buijs, Tamara J; Vilar, Bruno; Tan, Chun-Hsiang; McNaughton, Peter A

Buijs, Tamara J; Vilar, Bruno; Tan, Chun-Hsiang; McNaughton, Peter A.

Affiliation

Buijs TJ; Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Vilar B; Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Tan CH; Department of Pharmacology, University of Cambridge, Cambridge, UK.
McNaughton PA; Wolfson Centre for Age-Related Diseases, King's College London, London, UK.

EMBO J ; 42(3): e111348, 2023 02 01.

Article in En | MEDLINE | ID: mdl-36524441

Subject(s)

Calcium Channels; Calcium; Humans; Calcium Channels/genetics; Calcium Channels/metabolism; Calcium/metabolism; HEK293 Cells; Calcium Signaling/physiology; Neurons/metabolism; ORAI1 Protein/genetics; Stromal Interaction Molecule 1/genetics; Neoplasm Proteins/genetics

Key words

ORAI; STIM; calcium influx; cold sensation; sensory neuron

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Calcium Limits: Humans Language: En Journal: EMBO J Year: 2023 Type: Article Affiliation country: United kingdom

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