The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis.

Osma-Garcia, Ines C; Capitan-Sobrino, Dunja; Mouysset, Mailys; Aubert, Yann; Maloudi, Orlane; Turner, Martin; Diaz-Muñoz, Manuel D

Osma-Garcia, Ines C; Capitan-Sobrino, Dunja; Mouysset, Mailys; Aubert, Yann; Maloudi, Orlane; Turner, Martin; Diaz-Muñoz, Manuel D.

Affiliation

Osma-Garcia IC; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France.
Capitan-Sobrino D; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France.
Mouysset M; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France.
Aubert Y; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France.
Maloudi O; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France.
Turner M; Immunology Program, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Diaz-Muñoz MD; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, CHU Purpan, Toulouse 31024, France. Electronic address: manuel.diaz-munoz@inserm.fr.

Cell Rep ; 41(12): 111869, 2022 12 20.

Article in En | MEDLINE | ID: mdl-36543128

Subject(s)

Lymphopoiesis; Poly(A)-Binding Proteins; T-Cell Intracellular Antigen-1/genetics; T-Cell Intracellular Antigen-1/metabolism; Poly(A)-Binding Proteins/metabolism; Lymphopoiesis/genetics; RNA Splicing; RNA Splice Sites; DNA Repair; DNA Damage

Key words

B cell development; CP: Developmental biology; CP: Molecular biology; DNA damage repair; RNA splicing; TIA1; TIAL1; apoptosis; immunoglobulin VDJ recombination; post-transcriptional gene regulation; pro-B cells; progenitor B cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poly(A)-Binding Proteins / Lymphopoiesis Language: En Journal: Cell Rep Year: 2022 Type: Article Affiliation country: France

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