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Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscina.
Kotajima, Mihaya; Choi, Jae-Hoon; Kondo, Mitsuru; D'Alessandro-Gabazza, Corina N; Toda, Masaaki; Yasuma, Taro; Gabazza, Esteban C; Miwa, Yukihiro; Shoda, Chiho; Lee, Deokho; Nakai, Ayaka; Kurihara, Toshihide; Wu, Jing; Hirai, Hirofumi; Kawagishi, Hirokazu.
Affiliation
  • Kotajima M; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Choi JH; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Kondo M; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • D'Alessandro-Gabazza CN; Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Toda M; Research Institute for Mushroom Science, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Yasuma T; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Gabazza EC; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
  • Miwa Y; Department of Immunology, Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 524-8507, Japan.
  • Shoda C; Department of Immunology, Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 524-8507, Japan.
  • Lee D; Department of Immunology, Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 524-8507, Japan.
  • Nakai A; Department of Immunology, Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 524-8507, Japan.
  • Kurihara T; Department of Ophthalmology, Keio University School of Medicine, 35 Shina-nomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Wu J; Department of Ophthalmology, Keio University School of Medicine, 35 Shina-nomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Hirai H; Department of Ophthalmology, Keio University School of Medicine, 35 Shina-nomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Kawagishi H; Department of Ophthalmology, Keio University School of Medicine, 35 Shina-nomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Molecules ; 27(24)2022 Dec 15.
Article in En | MEDLINE | ID: mdl-36558053
ABSTRACT
Two compounds 1 and 2 were isolated from the culture broth of Lepista luscina. This is the first time that compound 1 was isolated from a natural source. The structure of compound 1 was identified via 1D and 2D NMR and HRESIMS data. Compounds 1 and 2 along with 8-nitrotryptanthrin (4) were evaluated for their biological activities using the A549 lung cancer cell line. As a result, 1 and 2 inhibited the expression of Axl and immune checkpoint molecules. In addition, compounds 1, 2 and 4 were tested for HIF inhibitory activity. Compound 2 demonstrated statistically significant HIF inhibitory effects on NIH3T3 cells and 1 and 2 against ARPE19 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immune Checkpoint Proteins / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immune Checkpoint Proteins / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Type: Article Affiliation country: Japan