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A NIR BODIPY-based ratiometric fluorescent probe for HClO detection with high selectivity and sensitivity in real water samples and living zebrafish.
Liang, Yueyin; Chen, Zhen; Liu, Qianting; Huang, Haiting; Meng, Zhiyuan; Gong, Shuai; Wang, Zhonglong; Wang, Shifa.
Affiliation
  • Liang Y; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Chen Z; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Liu Q; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Huang H; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Meng Z; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Gong S; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
  • Wang Z; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: wang_zhon
  • Wang S; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: wangshifa
Spectrochim Acta A Mol Biomol Spectrosc ; 290: 122268, 2023 Apr 05.
Article in En | MEDLINE | ID: mdl-36580754
ABSTRACT
Hypochlorous acid (HClO) plays an important role in many physiological and pathological activities. In this work, a novel BODIPY-based Near-infrared (NIR) ratiometric fluorescent probe BODIPY-Hyp was designed for the rapid detection of HClO. The probe BODIPY-Hyp was highly selective and sensitive for HClO with a low detection limit of 16.74 nM and short response time of less than 60 s. The probe BODIPY-Hyp in response to HClO exhibited a significant blue-shifted fluorescence emission from 700 nm to 530 nm, and its fluorescence intensity ratio (I530 nm/I700 nm) increased about 1200 times before and after adding HClO. Moreover, the reaction mechanism of BODIPY-Hyp with HClO was verified by HRMS analysis, 1H NMR titration and DFT calculations. Furthermore, BODIPY-Hyp was successfully processed into a portable test strip-based device for the detection of HClO. In addition, the probe BODIPY-Hyp could be used in real time to monitor the levels of HClO in living zebrafish larvae. In conclusion, BODIPY-Hyp has great application potential in the life and environmental sciences.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Fluorescent Dyes Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Fluorescent Dyes Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: China