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Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults.
Rizvi, Batool; Sathishkumar, Mithra; Kim, Soyun; Márquez, Freddie; Granger, Steven J; Larson, Myra S; Miranda, Blake A; Hollearn, Martina K; McMillan, Liv; Nan, Bin; Tustison, Nicholas J; Lao, Patrick J; Brickman, Adam M; Greenia, Dana; Corrada, Maria M; Kawas, Claudia H; Yassa, Michael A.
Affiliation
  • Rizvi B; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Sathishkumar M; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Kim S; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Márquez F; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Granger SJ; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Larson MS; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Miranda BA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Hollearn MK; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • McMillan L; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Nan B; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Statistics, University of California, Irvine, Irvine, CA, USA.
  • Tustison NJ; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
  • Lao PJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, Vage
  • Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, Vage
  • Greenia D; Department of Neurology, School of Medicine, University of California, Irvine, CA, USA.
  • Corrada MM; Department of Neurology, School of Medicine, University of California, Irvine, CA, USA; Department of Epidemiology, University of California, Irvine, CA, USA.
  • Kawas CH; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA; Department of Neurology, School of Medicine, University of California, Irvine, CA, USA.
  • Yassa MA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA; Department of Neurology, School of Medicine, University of California, Irvine, CA, USA. Electronic address: michael.yassa
Neuroimage Clin ; 37: 103308, 2023.
Article in En | MEDLINE | ID: mdl-36586358
ABSTRACT
White matter hyperintensities are a marker of small vessel cerebrovascular disease that are strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well-documented in aging and Alzheimer's disease and is associated with memory decline. Here, we assessed the relationship between lobar white matter hyperintensities, medial temporal lobe subregional volumes, and hippocampal memory in older adults. We collected MRI scans in a sample of 139 older adults without dementia (88 females, mean age (SD) = 76.95 (10.61)). Participants were administered the Rey Auditory Verbal Learning Test (RAVLT). Regression analyses tested for associations among medial temporal lobe subregional volumes, regional white matter hyperintensities and memory, while adjusting for age, sex, and education and correcting for multiple comparisons. Increased occipital white matter hyperintensities were related to worse RAVLT delayed recall performance, and to reduced CA1, dentate gyrus, perirhinal cortex (Brodmann area 36), and parahippocampal cortex volumes. These medial temporal lobe subregional volumes were related to delayed recall performance. The association of occipital white matter hyperintensities with delayed recall performance was fully mediated statistically only by perirhinal cortex volume. These results suggest that white matter hyperintensities may be associated with memory decline through their impact on medial temporal lobe atrophy. These findings provide new insights into the role of vascular pathologies in memory loss in older adults and suggest that future studies should further examine the neural mechanisms of these relationships in longitudinal samples.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / White Matter Type of study: Risk_factors_studies Limits: Aged / Female / Humans Language: En Journal: Neuroimage Clin Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / White Matter Type of study: Risk_factors_studies Limits: Aged / Female / Humans Language: En Journal: Neuroimage Clin Year: 2023 Type: Article Affiliation country: United States