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A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.
Takase, Shohei; Hiroyama, Takashi; Shirai, Fumiyuki; Maemoto, Yuki; Nakata, Akiko; Arata, Mayumi; Matsuoka, Seiji; Sonoda, Takeshi; Niwa, Hideaki; Sato, Shin; Umehara, Takashi; Shirouzu, Mikako; Nishigaya, Yosuke; Sumiya, Tatsunobu; Hashimoto, Noriaki; Namie, Ryosuke; Usui, Masaya; Ohishi, Tomokazu; Ohba, Shun-Ichi; Kawada, Manabu; Hayashi, Yoshihiro; Harada, Hironori; Yamaguchi, Tokio; Shinkai, Yoichi; Nakamura, Yukio; Yoshida, Minoru; Ito, Akihiro.
Affiliation
  • Takase S; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan.
  • Hiroyama T; Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan.
  • Shirai F; Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
  • Maemoto Y; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan.
  • Nakata A; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
  • Arata M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
  • Matsuoka S; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
  • Sonoda T; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
  • Niwa H; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, 230-0045, Japan.
  • Sato S; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, 230-0045, Japan.
  • Umehara T; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, 230-0045, Japan.
  • Shirouzu M; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, 230-0045, Japan.
  • Nishigaya Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, 329-0114, Japan.
  • Sumiya T; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, 329-0114, Japan.
  • Hashimoto N; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, 329-0114, Japan.
  • Namie R; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, 329-0114, Japan.
  • Usui M; Support Unit for Bio-Material Analysis, Research Resources Division, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
  • Ohishi T; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu, Shizuoka, 410-0301, Japan.
  • Ohba SI; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu, Shizuoka, 410-0301, Japan.
  • Kawada M; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu, Shizuoka, 410-0301, Japan.
  • Hayashi Y; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan.
  • Harada H; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan.
  • Yamaguchi T; RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama, Kanagawa, 230-0045, Japan.
  • Shinkai Y; Cellular Memory Laboratory, Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan.
  • Nakamura Y; Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan.
  • Yoshida M; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan. yoshidam@riken.jp.
  • Ito A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan. yoshidam@riken.jp.
Nat Commun ; 14(1): 23, 2023 01 12.
Article in En | MEDLINE | ID: mdl-36635268
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Long Noncoding / Anemia, Sickle Cell Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Long Noncoding / Anemia, Sickle Cell Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Type: Article Affiliation country: Japan