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Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase.
Iida, Hiroki; Onuma, Takashi; Nakashima, Daiki; Mizutani, Daisuke; Hori, Takamitsu; Ueda, Kyohei; Hioki, Tomoyuki; Kim, Woo; Enomoto, Yukiko; Doi, Tomoaki; Matsushima-Nishiwaki, Rie; Yamaguchi, Shinobu; Tachi, Junko; Tanabe, Kumiko; Ogura, Shinji; Iwama, Toru; Kozawa, Osamu; Tokuda, Haruhiko.
Affiliation
  • Iida H; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Onuma T; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Nakashima D; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Mizutani D; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Hori T; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Ueda K; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Hioki T; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Kim W; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Enomoto Y; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Doi T; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Matsushima-Nishiwaki R; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Yamaguchi S; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Tachi J; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Tanabe K; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Ogura S; Department of Dermatology, Kizawa Memorial Hospital, Minokamo, Japan.
  • Iwama T; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Kozawa O; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Tokuda H; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
PLoS One ; 18(1): e0279011, 2023.
Article in En | MEDLINE | ID: mdl-36638092
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tramadol Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tramadol Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: Japan