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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy.
Perez-Garcia, Georgina; Bicak, Mesude; Haure-Mirande, Jean-Vianney; Perez, Gissel M; Otero-Pagan, Alena; Gama Sosa, Miguel A; De Gasperi, Rita; Sano, Mary; Barlow, Carrolee; Gage, Fred H; Readhead, Benjamin; Ehrlich, Michelle E; Gandy, Sam; Elder, Gregory A.
Affiliation
  • Perez-Garcia G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA.
  • Bicak M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Perez GM; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA.
  • Otero-Pagan A; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA.
  • Gama Sosa MA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; General Medical Research Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA.
  • De Gasperi R; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Sano M; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School
  • Barlow C; BrainCells Inc., La Jolla, CA 92037, USA; EScape Bio, South San Francisco, CA 94080, USA.
  • Gage FH; BrainCells Inc., La Jolla, CA 92037, USA; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Readhead B; Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ 85287, USA.
  • Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Gandy S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mount Sinai Alzheime
  • Elder GA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Me
Neurosci Lett ; 797: 137080, 2023 02 16.
Article in En | MEDLINE | ID: mdl-36657633
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Receptors, Metabotropic Glutamate / Tauopathies / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Neurosci Lett Year: 2023 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Receptors, Metabotropic Glutamate / Tauopathies / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Neurosci Lett Year: 2023 Type: Article Affiliation country: United States