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An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities.
Yang, Yenan; Li, Chonghui; Chen, Ziyin; Zhang, Yiyang; Tian, Qing; Sun, Meiling; Zhang, Shuai; Yu, Miao; Wang, Gang.
Affiliation
  • Yang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
  • Li C; State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • Chen Z; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
  • Zhang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
  • Tian Q; State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • Sun M; State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • Zhang S; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
  • Yu M; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
  • Wang G; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Nucleic Acids Res ; 51(5): 2137-2150, 2023 03 21.
Article in En | MEDLINE | ID: mdl-36718943
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mediator Complex / Intellectual Disability Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2023 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mediator Complex / Intellectual Disability Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2023 Type: Article Affiliation country: China