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Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Modukuri, Ram K; Monsivais, Diana; Li, Feng; Palaniappan, Murugesan; Bohren, Kurt M; Tan, Zhi; Ku, Angela F; Wang, Yong; Madasu, Chandrashekhar; Li, Jian-Yuan; Tang, Suni; Miklossy, Gabriella; Palmer, Stephen S; Young, Damian W; Matzuk, Martin M.
Affiliation
  • Modukuri RK; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Monsivais D; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Li F; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Palaniappan M; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Bohren KM; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Tan Z; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Ku AF; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Wang Y; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Madasu C; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Li JY; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Tang S; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Miklossy G; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Palmer SS; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Young DW; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
  • Matzuk MM; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas77030, United States.
J Med Chem ; 66(3): 2143-2160, 2023 02 09.
Article in En | MEDLINE | ID: mdl-36719862
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Signal Transduction Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Signal Transduction Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States