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Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
Gillis, Eric P; Parcella, Kyle; Bowsher, Michael; Cook, James H; Iwuagwu, Christiana; Naidu, B Narasimhulu; Patel, Manoj; Peese, Kevin; Huang, Haichang; Valera, Lourdes; Wang, Chunfu; Kieltyka, Kasia; Parker, Dawn D; Simmermacher, Jean; Arnoult, Eric; Nolte, Robert T; Wang, Liping; Bender, John A; Frennesson, David B; Saulnier, Mark; Wang, Alan Xiangdong; Meanwell, Nicholas A; Belema, Makonen; Hanumegowda, Umesh; Jenkins, Susan; Krystal, Mark; Kadow, John F; Cockett, Mark; Fridell, Robert.
Affiliation
  • Gillis EP; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Parcella K; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Bowsher M; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Cook JH; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Iwuagwu C; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Naidu BN; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Patel M; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Peese K; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Huang H; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Valera L; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Wang C; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Kieltyka K; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Parker DD; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Simmermacher J; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Arnoult E; Molecular Design, GSK, Collegeville, Pennsylvania 19426, United States.
  • Nolte RT; Protein Cellular and Structural Sciences, GSK, Collegeville, Pennsylvania 19426, United States.
  • Wang L; Protein Cellular and Structural Sciences, GSK, Collegeville, Pennsylvania 19426, United States.
  • Bender JA; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.
  • Frennesson DB; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Cambridge, Massachusetts 02142, United States.
  • Saulnier M; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.
  • Wang AX; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.
  • Meanwell NA; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.
  • Belema M; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.
  • Hanumegowda U; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Jenkins S; ViiV Discovery, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Krystal M; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Kadow JF; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Cockett M; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.
  • Fridell R; ViiV Discovery, ViiV Healthcare, Branford, Connecticut 06405, United States.
J Med Chem ; 66(3): 1941-1954, 2023 02 09.
Article in En | MEDLINE | ID: mdl-36719971
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Anti-HIV Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Anti-HIV Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States