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A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Kaneshige, Atsunori; Bai, Longchuan; Wang, Mi; McEachern, Donna; Meagher, Jennifer L; Xu, Renqi; Wang, Yu; Jiang, Wei; Metwally, Hoda; Kirchhoff, Paul D; Zhao, Lijie; Jiang, Hui; Wang, Meilin; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A; Wang, Shaomeng.
Affiliation
  • Kaneshige A; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Bai L; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Wang M; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • McEachern D; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Meagher JL; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Xu R; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  • Wang Y; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Jiang W; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Metwally H; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Kirchhoff PD; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Zhao L; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Jiang H; Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA.
  • Wang M; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Wen B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Sun D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Stuckey JA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Wang S; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Nat Chem Biol ; 19(6): 703-711, 2023 06.
Article in En | MEDLINE | ID: mdl-36732620
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: STAT5 Transcription Factor / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: STAT5 Transcription Factor / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2023 Type: Article Affiliation country: United States