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Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.
Kokot, Maja; Weiss, Matjaz; Zdovc, Irena; Senerovic, Lidija; Radakovic, Natasa; Anderluh, Marko; Minovski, Nikola; Hrast, Martina.
Affiliation
  • Kokot M; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, 1000, Ljubljana, Slovenia.
  • Weiss M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, 1000, Ljubljana, Slovenia.
  • Zdovc I; Institute of Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000, Ljubljana, Slovenia.
  • Senerovic L; Laboratory for Microbial Molecular Genetics and Ecology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11 042, Belgrade, Serbia.
  • Radakovic N; Laboratory for Microbial Molecular Genetics and Ecology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11 042, Belgrade, Serbia.
  • Anderluh M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, 1000, Ljubljana, Slovenia.
  • Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia. Electronic address: nikola.minovski@ki.si.
  • Hrast M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, 1000, Ljubljana, Slovenia. Electronic address: martina.hrast@ffa.uni-lj.si.
Eur J Med Chem ; 250: 115160, 2023 Mar 15.
Article in En | MEDLINE | ID: mdl-36753879
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methicillin-Resistant Staphylococcus aureus Limits: Animals Language: En Journal: Eur J Med Chem Year: 2023 Type: Article Affiliation country: Slovenia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methicillin-Resistant Staphylococcus aureus Limits: Animals Language: En Journal: Eur J Med Chem Year: 2023 Type: Article Affiliation country: Slovenia